KEY WORDS | neurobiology, neuroscience, metabolism |
CITY | Bordeaux |
COUNTRY | France |
DETAILS OF THE OFFER | Working place: Neurocentre Magendie Missions: We are seeking a highly motivated PhD student researcher to join the Energy Balance and Obesity research team at the INSERM Unit U1215, Neurocentre Magendie in Bordeaux, France. The overall aim of the team is to elucidate the neurobiological mechanisms underlying the regulation of feeding and systemic metabolism. The Ghostbuster project will elucidate the molecular and functional heterogeneity of hypothalamic neuroendocrine neurons using state-of-the-art single-cell molecular and functional profiling methods. We will ‘hunt’ novel populations of ‘ghost’ neurons in the neuroendocrine hypothalamus that are characterised by high functional plasticity and atypical identity. A multidisciplinary approach will be used to achieve this goal, combining lineage tracing strategies, nutritional interventions, single cell profiling of hypothalamic neurons, bioinformatic analysis and viral-based tools for targeting ghost cell-related genes. These strategies will be combined with behavioural, metabolic and hormonal assessments of mouse models of ghost neuron loss or gain of function under physiological conditions and following exposure to obesogenic diets.
Qualifications: Highly motivated candidate and strongly interested in experimental neuroscience, neurophysiology, neuroendocrinology, hypothalamus, energy balance regulation, and obesity.
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TYPE OF JOB | Thesis - PhD |
TYPE OF CONTRACT | CDD (Temporary / 3 years) fully funded through an ERC funded project |
EMPLOYMENT START DATE | SEP 2024 |