The Institut de Biologie Paris-Seine and the Institut du Fer à Moulin will merge in 2025 into a single Institute located on the Pierre & Marie Curie campus (Jussieu) of Sorbonne University. This “Fédération de Recherche” will be composed of four research units hosting a total of 45 teams, which decipher basic principles governing development, nervous system function, physiology and genome evolution. Interdisciplinarity is a central asset of the future institute. A quarter of the teams have background from physics, mathematics, computational sciences or chemistry and a dedicated program has been implemented to foster interdisciplinary research (i-Bio). The Institute benefits from shared high-end facilities for imaging, animal housing and phenotyping, bioinformatics, and protein biochemistry.