République Française Inserm
Institut thématique Neurosciences, sciences cognitives, neurologie, psychiatrie

Postdoctoral Position - Systems Biology of Neuronal Vulnerability in Neurodegenerative Diseases, Paris

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  • Type d'offre : CDD
  • Ville : Paris
  • Statut : Available
Date d'arrivée à l'ITMO : Jeudi 23 Novembre 2023

Postdoctoral Position - Systems Biology of Neuronal Vulnerability in Neurodegenerative Diseases, Paris

KEY WORDS

neurodegenerative disorders, machine-learning, neuroscience

CITY

Paris

COUNTRY

France

DETAILS OF THE OFFER

Working place:  Brain-C Lab, Institute of Biology Paris-Seine (IBPS), CNRS UMR 8256

Missions:

the project will address outstanding questions about the temporal and molecular dynamic of neurodegenerative disorders and define new therapeutic rationales for early-stage intervention in these disorders. The successful applicant will use BioGemix —our machine learning platform for biological precision in leveraging complex omics data— to analyze omics data (e.g., epigenomic data, transcriptomic data) obtained in models of amyotrophic lateral sclerosis (ALS) and compare resulting models to computational models of neurodegenerative disorders such as Huntington’s disease (HD). In addition to using existing approaches (feature selection, network inference, shape analysis: see below), the successful applicant will also have the possibility to develop innovative machine-learning approaches for modeling and simulating gene regulatory networks and for optimal target selection, in collaboration with mathematicians and bioinformaticians inside and outside the team. This position is a unique opportunity to further develop research expertise and skills in a multidisciplinary team and network of direct collaborators that cover systems modeling, cellular neurobiology and preclinical/clinical research.

 

Qualifications:

The candidates are expected to be highly-qualified and to have strong collaborative skills and commitment to team work along with strong ability to work independently, and to have track record of expertise & writing papers as demonstrated by publications and pre-prints. The position is full time and on site, and candidates should have less than 5 years of postdoctoral experience and a strong interest for research in biology.

Candidates should hold a Ph.D. in Informatics/Bioinformatics or Mathematics or Probability & Statistics or Physics. Candidates that hold a diploma from high-profile Engineer Schools (e.g. Ecole Polytechnique, Supelec, Centrale, EPFL, ETZ) are welcome to apply.

  • Demonstrated experience and autonomy in probability and statistics for the analysis of complex datasets (probabilistic models, R)
  • Good autonomy in machine programming (at least one of the following languages: Python, C/C++, Java).
  • Skills in database management or web technologies (javascript, Php) are desirable but not mandatory.
  • Knowledge of genome sciences and omics technologies will be a plus

 

TYPE OF JOB

Post-Doctorat - Post-Doctoral position

TYPE OF CONTRACT

CDD (Temporary / 2 years)

Contact

Interested candidates should apply immediately by sending a letter of motivation, a full CV, and the names and emails of two-three references to christian.neri@inserm.fr and lucile.megret@sorbonne-universite.fr