Two ERC-funded postdoctoral positions on motor control

KEY WORDS

CITY

COUNTRY

France

DETAILS O THE OFFER

Working place:  team Neuronal Circuits and Motor Control, headed by Dr.Bouvier / NeuroPsi / CNRS

Missions:

We study the neuronal basis for movement from an integrated perspective. This includes cells types and microcircuits for the execution of movements, as well as the long-range connectivity between the brain and the spinal cord for coordinating whole-body actions. We are looking for two motivated scientists to explore the diversity and specialization of descending circuits from the brainstem for the orchestration of complex and adaptive movements at the functional, connectomics and genetics levels.

Applicants should be interested in systems and motor neuroscience, have a constructive team-spirit, and have some of the following skills:

Project 1:

To investigate the diversity of specific brainstem neurons from the gene expression standpoint, and to provide novel molecular markers for functionally- and connectivity-defined populations. Approaches will combine mouse genetics, viral labelling, high-throughput single-nucleus profiling, and histology.

Relevant skills:

• Molecular biology including tissue dissociation and FACS sorting;
• RNA sequencing and genomic data analysis ideally at the single cell or single nucleus level;
• Interest in learning experimental approaches on mice including surgical procedures and viral tools.

Project 2:

To investigate the functional organization of specific brainstem neurons, through the characterization of their connectivity, activity and function for movement execution. Approaches will combine viral circuit tracings in mice with multi-site functional imaging, electrophysiology and optogenetics in vivo, and behavioral analysis.

Relevant skills:

• Rodent stereotaxic surgery for circuits tracings and neuronal manipulations;
• In vivo calcium imaging and/or electrophysiological recordings and/or optogenetics;
• Movement analysis using video-tracking;
• Minimal skills in programming or in bioengineering will be a valuable asset.

You would be joining a dynamic, international, and well-equipped team, housed in a brand-new multidisciplinary Institute dedicated to brain function from genes to artificial intelligence, at the heart of the Paris-Saclay cluster. 

TYPE OF JOB

TYPE OF CONTRACT

CDD (temporary / 2 years / possible extension based on advancement)

EMPLOYMENT START DATE