République Française Inserm
Institut thématique Neurosciences, sciences cognitives, neurologie, psychiatrie

Post-doctoral position - Epigenomic mechanisms of drug addiction

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  • Type d'offre : CDD
  • Ville : Strasbourg
  • Statut : Available
Date d'arrivée à l'ITMO : Jeudi 07 Septembre 2023

Post-doctoral position – Epigenomic mechanisms of drug addiction

KEY WORDS

epigenetic plasticity, mental health, neuroscience

CITY

Strasbourg

COUNTRY

France

DETAILS OF THE OFFER

Working place: Institute of Cellular and Integrative Neuroscience (INCI, CNRS UPR3212)

Missions:

The recruited fellow will join our project dedicated to the understanding of epigenetic plasticity in substance use disorders, or addiction. Our work mostly focuses on DNA methylation (WGBS, EM-seq) and histone modifications (Cut&Tag), with an emphasis on sex-differences. The originality of the project resides in complementary studies conducted in humans and mice. In Human, we will investigate post-mortem brain tissue from addicted individuals carefully characterized through psychological autopsy (collaboration with the Montréal Brain Bank). In the mouse, we will model volitional reward-seeking and compulsive behaviors in operant paradigms, and manipulate the epigenetic enzymatic machinery (conditional knockout of DNA methyltransferases).

The recruited fellow will be mainly responsible for molecular biology work, processing of biological samples, and preparation of NGS libraries. A dedicated staff and collaborations are already in place for behavioral modelling (Dr Emmanuel Darcq, CRBS, Strasbourg) and bioinformatic data processing (Dr Anais Bardet, IGBMC, Strasbourg).

Qualifications:

 

A molecular biologist with:

  • Experience in the use of next-generation sequencing for epigenomic analysis,
  • Strong interest in neuroscience and mental health.

+ info

 

TYPE OF JOB

Post-doctoral Position

TYPE OF CONTRACT

CDD (temporary / 24 months)

REMUNERATION

Depending on experience; full health and social coverage included

APPLICATION DEADLINE

31 DEC 2023

EMPLOYMENT START DATE

15 OCT 2023 (flexible, ideally OCT– NOV 2023)
Contact

To apply : please contact Pierre-Eric Lutz by email: pierreeric.lutz@gmail.com

When applying, please include a CV, a letter of interest (either in English or French), your publication record, and the names and contact of at least two references. There is no strict deadline, but priority will be given to applications sent by September 15th.