KEY WORDS | astrocyte, physiopathology, neuroscience |
CITY | Paris |
COUNTRY | France |
DETAILS OF THE OFFER | Working place: Center for interdisciplinary research in Biology, Collège de France, Paris. The Physiology and physiopathology of the gliovascular unit team is looking for a junior post doctorant or an engineer, to describe the morphology of perivascular astrocyte processes in the brain, in normal, pathological contexts and during postnatal development. Astrocytes are brain glial cells that have a predominant influence on the cerebrovascular system. The astroglial regulation of the cerebrovascular system operates at the level of the gliovascular unit, a specialized interface comprising astrocyte perivascular processes that fully sheath the brain vessels. To date, the exact morphology of this interface is unknown. Our objective is to generate the first detailed map of gliovascular interactions in the mouse cerebral cortex. The project is based on an already set confocal fluorescent microscopy procedure on fixed cleared mouse brain samples. The candidate will have to develop a multiparametric computational approach to describe the organization of the perivascular astrocyte processes. The candidate must have a strong background in confocal microscopy and image analysis and be independent on the development of new quantitative analysis protocols. |
TYPE OF JOB | Postdoc |
TYPE OF CONTRACT | CDD (temporary / 2.5 years) |
APPLICATION DEADLINE | OCT 2023 |
EMPLOYMENT START DATE | Starting from OCT 2023 |