You are passionate about neurodevelopmental genetic disorders, and you want to contribute to major discoveries impacting patients’ health and care all in a state-of-the-art research environment? The Baulac lab at the ICM is the place for you!
A fully-funded 36-months postdoc position is opening starting in April 2022. This collaborative project funded by ERANET Neuron gathers a consortium of 3 renowned European groups (Baulac lab in Paris, Jabaudon lab in Geneva, Bonev lab in Munich). We are looking for a highly qualified and motivated postdoctoral fellow with expertise in mouse modeling and genetic engineering to complete our team and develop new disease models to better understand the biological mechanism underlying mosaic cortical malformations.
MAIN MISSIONS
Our laboratory investigates the genetic etiology and the pathomechanisms underlying developmental epilepsies, with a special focus on brain somatic mosaicism in cortical malformations, notably focal cortical dysplasia (FCD). To do so, we employ a multi-disciplinary approach integrating genetic/genomic studies in human brain tissues and disease modeling in vitro and in vivo.
The main aim of the project is to understand the molecular and cellular bases of focal cortical dysplasia and epileptogenesis. To achieve this, FCD somatic mutations will be introduced in the developing mouse brain to reproduce the disease phenotype, and study the underlying cellular and molecular mechanisms. The successful candidate should be able to use multiple techniques such as genetic engineering and Crispr-editing, in utero electroporation, high\u0002throughput in vivo screening, imaging and single-cell omics
PROFILE
- Ph.D. in Neuroscience/Molecular Biology, and have a strong publication record including at least one first-author paper
- Knowledge of cell and molecular biology, genetics and molecular genetics, and neuroscience/neurodevelopment.
- Strong experience in mouse experimentation, transgenic mice generation and genome editing
SKILLS
We are looking for an open and collaborative person who likes teamwork and enjoy sharing knowledge - Organizational skills, efficient planning, autonomy and ability to conceptualize new ideas are required - Fluency in English is required, fluency in French is not required to work in our team/institute, even if learning French is encouraged
To candidate, please send a CV and a motivation letter to stephanie.baulac@icm-institute.org
More information on: institutducerveau-icm.org/fr/annonce/postdoctoral-fellow-2-in-genetic-engineering-and-mouse-modeling/