The main aim of the project is to understand the molecular and cellular bases of focal cortical dysplasia and epileptogenesis, notably the developmental mechanisms leading to FCD. To achieve this, genetic engineering approaches will be applied to generate hiPSC-derived mosaic brain organoids mimicking FCD somatic mutations. The successful candidate should be able to generate and characterize cortical organoids using different approaches, including Crispr-editing, 3D cell culture, high-throughput screening, imaging and single-cell omics
Date de fin de publication :
01/06/2022
Type d'emploi
Post-Doctorat - Post-Doctoral position
Type de contrat
CDD
Date limite de candidature
01/06/22
Date début de fonction
01/04/2022
Information contact
Stéphanie Baulac : stephanie.baulac@icm-institute.org Paris Brain Institute - Institut du Cerveau - ICM Hôpital Pitié-Salpêtrière - 47, bd de l'hôpital - 75013 Paris Tél : +33 (0)1 57 27 43 39
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