Offre n°346 : Post-doc in neuroscience (prolactin-sensitive hypothalamus)

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  • Type d'offre : Postdoctoral position
  • Ville : Montpellier
  • Statut : Recrutement en cours
Date d'arrivée à l'ITMO : Lundi 03 Juin 2019

Post-doc in neuroscience
"Prolactin-sensitive hypothalamus"

A 2-year postdoctoral position is available at Institute of Functional genomic (Montpellier France) in the department of Physiology in the team “NETWORKS AND RHYTHMS IN ENDOCRINE GLANDS” headed by Patrice Mollard (1). Prolactin (PRL) influences a wide range of physiological functions helping the mother to adapt to the physiological demands of pregnancy and subsequent lactation. In the recent years we pioneered approaches to monitor in vivo PRL secretion (2) and TIDA neuron activities (calcium imaging, amperometry of DA release) as well as ex vivo, on brain slices (electrophysiology)(3, 4).
The post-doc project (ANR-DFG) will explore how arcuate PRL?sensitive DA neural circuits translate dynamic PRL levels into distinct functions linked to reproduction, metabolism and lactation. To do this, the postdoctoral fellow will use in vivo imaging techniques (GRIN lens, photometry), optogenetic tools and release assays (amperometry, mouse hormone Elisa) to study this endocrine-brain dialog in male versus virgin and lactating female mice. This project will be in collaboration with Ulrich Boehm, Homburg univ.,(specialist in scRNA-Seq, CRISPR-Cas9, and neuronal tracing).

Desired skills and experience
We are looking for highly motivated, independent and driven candidates. The successful applicant will have a strong background in Neuroscience, preferentially with knowledge in the area of neuroendocrinology. An ability to independently carry out experimental research projects is required, as are good communication skills in spoken and written English. Experience with animal handling, in vivo imaging and electrophysiology techniques, is an advantage. Start September 2019.

Agnès Martin :
Patrice Mollard :

Application process
Application must contain the following documents in English:
A complete curriculum vitae, including date of the thesis defense, title of the thesis, previous
academic positions, academic title, current position, academic distinctions, and committee work
A complete list of publications
Names of three references
A summary of current work (no more than one page)

1. Le Tissier P, Campos P, Lafont C, Romanò N, Hodson DJ, Mollard P. An updated view of hypothalamic-vascular-pituitary unit function and plasticity. Nat Rev Endocrinol. 2017 May;13(5):257-267.
2. Guillou, A., Romano, N., Steyn, F., Abitbol, K., Le Tissier, P., Bonnefont, X., Chen, C., Mollard, P., and Martin, A. O. (2015) Assessment of lactotroph axis functionality in mice: longitudinal monitoring of PRL secretion by ultrasensitive-ELISA. Endocrinology 156, 1924-1930
3. Romano, N., Yip, S. H., Hodson, D. J., Guillou, A., Parnaudeau, S., Kirk, S., Tronche, F., Bonnefont, X., Le Tissier, P., Bunn, S. J., Grattan, D. R., Mollard, P., and Martin, A. O. (2013) Plasticity of hypothalamic dopamine neurons during lactation results in dissociation of electrical activity and release. The Journal of neuroscience : the official journal of the Society for Neuroscience 33, 4424-4433
4. Romano, N., Guillou, A., Hodson, D. J., Martin, A. O., and Mollard, P. (2017) Multiple-scale neuroendocrine signals connect brain and pituitary hormone rhythms. Proceedings of the National Academy of Sciences of the United States of America 114, 2379-2382



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