PhD THESIS GRANT
Evaluation of astrocyte dysfunction in Tauopathies
A PhD grant is open in our laboratory, funded by the Agence Nationale pour la Recherche (ANR), starting in Oct 2019. It is open to applications from high level students, coming from any university worldwide (France included).
Deposits of different abnormal forms of tau are associated with several neurodegenerative diseases collectively referred to as tauopathies. Tau is a protein that is highly enriched in neurons, yet Tau aggregates can also be found in astrocytes. Glial contribution to neurodegeneration in tauopathies has been overlooked.
The aim of the present PhD project is to understand the consequences of pathological tau expression in astrocytes. Using gene transfer-based model of Tauopathy by viral vectors in mice, we will evaluate
1 the nature of Tau species that accumulates in astrocytes using immunohistochemistry, in situ hybridization and microscopy;
2 the impact of Tau astrogliopathy on the complex morphology of astrocytes using confocal microscopy and 3D reconstruction;
3 calcium dynamics in astrocytes in living mice implanted with a miniature fluorescence microscope.
Knowledge and skills required for the thesis
The candidate should have earned an M2 degree or equivalent, with a solid knowledge of neurosciences. Expertise in animal surgery and histology would be appreciated. Fluency in English is a requirement. Experience abroad is also appreciated.
Applications should be sent to:
Karine Cambon (email@example.com)
Gilles Bonvento (firstname.lastname@example.org)
and should contain:
a motivation letter;
one or two supporting letters by academic staff or name(s) and email address of referees who know the candidate.
Our research center MIRCen (Molecular Imaging Research Center) is a preclinical research facility located in the CEA research center in Fontenay-aux-Roses (5km south of Paris) and gathers several platforms dedicated to the development of relevant animal models of human disease and to the evaluation of novel therapies (gene and cell-based therapies) in the field of neurodegenerative diseases. It is easily accessible by Tram or bus. http://jacob.cea.fr/drf/ifrancoisjacob/Pages/Departements/MIRCen/plan-mircen.aspx
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