24 months (starting in March/April 2019)
Role of retinoid signaling in the physiology and pathology of basal ganglia
Several lines of evidence indicate that retinoid signaling, best known for its developmental functions, is also critical for homeostasis and neuroprotection of adult nervous system. In particular, abnormal signaling of some retinoid receptors is associated with Huntington or Parkinson diseases and may contribute to their physiopathology whereas point mutations of such receptor(s) are causal factors of rare neurological disorders. The project aims at characterizing the mechanisms through which deficient or excessive retinoid signaling may contribute to neurodegeneration. The project will take advantage of classical and new genetic mouse models of neurodegenerative diseases and will involve genomic and functional studies in primary organotypic or neural cell cultures as well as in vivo analyses in mice with final objective to propose new therapeutic targets and strategies of treatment. The project will be carried out at IGBMC (Strasbourg-Illkirch), an international research institute located in the heart of dynamic research region at crossroads of France, Germany and Switzerland. It will benefit from state-of-the-art infrastructure and international collaborations which include world clinical experts in neurology.
We are looking for highly motivated post-doctoral fellow with solid research experience in molecular and cellular biology (experience in neurobiology, primary mammalian cell/organotypic cultures are mandatory). Experience in mitochondrial biology and calcium signaling will be of great asset. The ability to work in an English speaking team and good communication skills are required. The ideal candidate should be able to bring original input to the 2 year challenging project, write papers and projects, and participate in animating team’s life.
Applicants should submit their complete application file:
- motivation letter
- publication list
- contact to at least two reference scientists
in one PDF file by email.
Dr Wojciech Krezel (Research Director at INSERM)
IGBMC, 1, rue L.Fries, 67404 Illkirch (CU Strasbourg), France