24 months (starting in February/March 2019)
New targets and pathways in neuroprotection
The project aims at identifying mechanisms of neurodegeneration with the main focus on small bioactive molecules, which deficits were observed during aging and further exacerbated in several neurodegenerative diseases including Alzheimer or Parkinson disease. Such bioactive molecules may act as ligands for transcription factors and are important for adaptive reprogramming of the organism, but their study is impeded due to lack of appropriate tools. We propose to use newly developed bioprobes to visualize such molecules and study their intracellular traffic between cellular organelles and its relevance for cell physiology and pathology. The same tools will be also employed to study blood-brain-barrier transfer and inter-cellular traffic of such molecules as mechanisms underlying adaptive processes and activity-dependent cellular communication. Studies will be carried out in mouse brain tissue preparations, organotypic and primary cell cultures using in vivo imaging and if necessary high-resolution imaging. Particular attention will go to neuron-neuron and neuron-astrocyte-microglia circuits.
We are looking for highly motivated post-doctoral fellow, with good English level and background in cellular biology and cellular communication. Sound experience in confocal imaging is required, whereas knowledge of life imaging techniques will be useful. Similarly, good knowledge of primary or cell culture techniques is necessary whereas experience with organotypic cultures will be useful. Although any technical expertise in molecular biology can be acquired in the team, any previous experience in these techniques will be of benefit. The candidate should be willing to bring personal input to the challenging multidisciplinary project, write scientific papers, contribute to preparation of research grants and participate in animating team’s life. The project will be carried out at IGBMC, Strasbourg, which lies in heart of dynamic tri-national region of Alsace and will benefit from proximity and collaborations with research teams in Basel and Freiburg.
Applicants should submit their complete application file:
- motivation letter
- publication list
- contact to at least two reference scientists in one PDF file
Dr Wojciech Krezel (Research Director at INSERM)
IGBMC, 1, rue L.Fries, 67404 Illkirch (CU Strasbourg), France