Post-doctoral position (2 years)
Laboratory ‘Physics for Medicine’, ESPCI, Paris
Functional Ultrasound imaging of spinal and cortical functions
in pain perception, in health and disease
Chronic pain diseases affect 30% of the European population. However, effective treatments are often missing.
Only 50% of patients receive appropriate alleviation, due to a lack of treatment specificity and efficacy, as a result of a current poor understanding of the underlying mechanisms.
The team ‘Pain and Neural Adaptation’ is studying the mechanisms of cortical plasticity that underlie the sensory or emotional aspect of pain.
In collaboration with M. Tanter (Institut Langevin, ESPCI), who developed functional ultrasound imaging (fUS 1) we are characterizing the alteration of brain networks using multimodal imaging (functional activations 2–5 and functional connectivity 6), in both anaesthetized and freely moving animals.
We previously showed that this technique that has a high spatial and temporal resolution can be adapted for the imaging of freely moving animals 7.
Using this unique approach, we want to establish markers of dysfunction in the spinal cord and brain of animal models of persistent pain and investigate if these alterations are reversed by classical treatments of either inflammatory or neuropathic pain.
PhD in Neuroscience (in vivo recordings would be a plus).
The applicant would ideally have some knowledge in Physics and/or signal analysis.
1. Mace E., E. et al. Functional ultrasound imaging of the brain. Nat Methods 8, 662–664 (2011).
2. Osmanski, B. F. et al. Functional ultrasound imaging reveals different odor-evoked patterns of vascular activity in the main olfactory bulb and the anterior piriform cortex. Neuroimage 95, 176–184 (2014).
3. Errico, C. et al. Transcranial functional ultrasound imaging of the brain using microbubble-enhanced ultrasensitive Doppler. Neuroimage 124, 752–761 (2016).
4. Sieu, L.-A. et al. EEG and functional ultrasound imaging in mobile rats. Nat Methods 12, 831–834 (2015).
5. Demene, C. et al. 4D microvascular imaging based on ultrafast Doppler tomography. Neuroimage 127, 472–483 (2015).
6. Osmanski, B.-F., Pezet, S., Ricobaraza, A., Lenkei, Z. & Tanter, M. Functional ultrasound imaging of intrinsic connectivity in the living rat brain with high spatiotemporal resolution. Nat. Commun. 5, 5023 (2014).
7. Tiran, E. et al. Transcranial Functional Ultrasound Imaging in Freely Moving Awake Mice and Anesthetized Young Rats without Contrast Agent. Ultrasound Med. Biol. 43, 1679–1689 (2017).
Sophie Pezet : firstname.lastname@example.org