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Offre n° 269 - Post-doc position in neurosciences


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Date d'arrivée à l'ITMO : Mardi 24 Juillet 2018

Post-doc position in Neurosciences

Paris, France

 


Collaboration between Durr (Brain and Spine Institute, ICM – Hôpital Pitié Salpêtrière) and Humbert laboratories (Grenoble Institute of Neurosciences – Inserm 1216 – University Grenoble Alpes).


While Huntington’s disease (HD) is a neurological disorder with late manifestation, there is evidence
that huntingtin, the protein causing HD, participates to several steps of cortical development. These
mechanisms are deregulated in HD conditions leading to abnormal cortical development. The goal of
the postdoctoral project is to further study the molecular mechanisms by which HTT mediates its role
during brain development and to assess how this may impact on adult brain and behavior.

 

We are seeking a highly motivated scientist. Experience in cellular and mouse biology is required.
Additional knowledge in gene expression profiling, cortical development and neurological disorders would be a bonus. The position is open this fall (2018).

 

The candidate will spend most of his/her time in ICM, Paris however regular stays in Grenoble are
anticipated.

 

Application
Candidates should apply by sending a CV, a brief outline of current research, scientific interests and career goals, as well as the name and contact details of at least two academic references to alexandra.durr@icm-institute.org and sandrine.humbert@inserm.fr
 

References (selection)
• Barnat M, Le Friec J, Benstaali C and Humbert S (2017). Huntingtin-mediated Multipolar-Bipolar Transition of Newborn Cortical Neurons is Critical for their Postnatal Neuronal Morphology. Neuron, 93, 99-114.
• Elias S, McGuire JR, Yu H and Humbert S (2015). Huntingtin is required for epithelial polarity through RAB11A mediated apical trafficking of PAR3-aPKC. Plos Biol, 13:e1002142.
• Molina-Calavita M, Barnat M, Elias S, Aparicio E, Piel M and Humbert S (2014). Mutant huntingtin affects cortical progenitor cell division and development of the mouse neocortex. J Neurosci, 34, 10034-10040.
• Ben M’Barek K, Pla P, Orvoen S, Benstaali, Godin JD, Gardier AM, Saudou F, David DJ and Humbert S (2013). Huntingtin Mediates Anxiety/Depression-related Behaviors and Hippocampal Neurogenesis. J Neurosci, 33, 8608-8620.

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