2 postdoc positions in Neuroscience
Ecole Normale Supérieure (Paris)
Team: “Glutamate Receptors and Excitatory Synapses” (http://www.biologie.ens.fr/neuronr/)
Head : Pierre PAOLETTI
Location: Institut de Biologie de l’Ecole Normale Supérieure (IBENS), Paris, France
Start date: Fall 2016
We seek to hire two highly motivated postdoctoral scientists to investigate 1/ the role of NMDA receptor molecular diversity in brain function, and 2/ the role of the synaptic microenvironment in the control of NMDA receptors and excitatory neurotransmission, using a combination of approaches including brain slice electrophysiology, molecular replacement, optogenetics, optopharmacology and genetically-modified mice.
The candidates should have a solid background in synaptic and cellular electrophysiology (patch-clamp in brain slices). The candidates should also show strong interest in molecular and cellular neuroscience with special focus on synaptic transmission and plasticity. A background in molecular biology and receptor pharmacology would be a plus.
The project is part of a recently awarded ERC Advanced Grant and is to be developed in the team of Pierre Paoletti at the Institut de Biologie de l’ENS (IBENS) in Paris, a team recognized internationally for its work on the structure, function and regulation of NMDA type glutamate receptors. The positions have 2 years of initial funding, with the possibility for extension.
IBENS is a leading biology institute in Europe that gathers several world-class researchers from diverse fields including genetics and genomics, developmental biology, systems biology and neuroscience. IBENS is located in the center of Paris (Latin Quarter) in a highly stimulating and dynamic environment, close to several other top research institutions (Institut Curie, Collège de France, ESPCI Paris Tech…).
Candidates should send a CV and a brief statement of research experience to Pierre Paoletti:
Selection of recent publications from the host team:
Gielen et al. (2008) Neuron, 57, 80-93.
Sensi et al. (2009) Nature Reviews Neuroscience, 10, 780-791.
Gielen et al. (2009) Nature, 459, 703-707.
Nozaki et al. (2011) Nature Neuroscience, 14, 1017-1022.
Mony et al. (2011) EMBO Journal, 30, 3134-3146.
Zhu et al. (2013) Nature Structural & Molecular Biology, 20(4), 477-485
Paoletti et al. (2013) Nature Reviews Neuroscience, 14(6), 383-400.
Zhu et al. (2014) PNAS (USA), 111, 6081-6086.
Stroebel et al. (2014), Journal of Neuroscience, 34(50), 16630-36
Vergnano et al. (2014) Neuron, 82(5), 1101-1114.
Zhu & Paoletti (2015) Current Opinion in Pharmacology, 20, 14-23.