République Française Inserm
Institut thématique Neurosciences, sciences cognitives, neurologie, psychiatrie

PhD offer: Role of voltage gated sodium channel in intracardiac neurons

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  • Type d'offre :
  • Ville : Poitiers
  • Statut : Recrutement en cours
Date d'arrivée à l'ITMO : Jeudi 13 Avril 2023

PhD offer: Role of voltage gated sodium channel in intracardiac neurons: new actors in cardiac channelopathies?

Job Information

Offer Description

Requirements

Additional Information

Work Location(s)

Where to apply

Contact

Job Information

Organisation/Company: Université de Poitiers

Research Field:

  • Biological sciences » Biology

  • Medical sciences » Health sciences

  • Neurosciences » Neurophysiology

Researcher Profile: First Stage Researcher (R1)

Country: France

Application Deadline: 5 May 2023 - 12:00 (Europe/Paris)

Type of Contract: Temporary

Job Status: Full-time

Offer Starting Date: 1 Oct 2023

Is the job funded through the EU Research Framework Programme? Not funded by an EU programme

Is the Job related to staff position within a Research Infrastructure? No

Offer Description

This PhD will take place within the PRéTI laboratory, well recognized for its strong expertise in cardiac physiology and electrophysiology localized at Poitiers University (Poitiers, France)..
The candidate will be supervised by Aurelien Chatelier, leader of the research axis Arrhythmias and Conduction Interfaces of the PRéTI laboratory.

Project:

Voltage gated sodium channels (VGSC) are major players of cellular excitability. Amongst them, Nav1.5 represent the major cardiac isoform which controls action potential initiation and propagation in the myocardium. Nav1.5 mutations have long been recognized to account for abnormalities of cardiac electrophysiology observed in Brugada syndrome (BS) or long QT type 3 (LQT3). The autonomic nervous system is suspected to be an important modulator of electrical disorders observed in this pathology. Interestingly, the final common pathway for cardiac neuronal autonomic control resides in the intrinsic cardiac nervous system, composed of intracardiac neurons (ICN). However, the influence of the intracardiac nervous system in the occurrence of these life-threatening arrhythmias has not yet been considered although ICN are now well known to efficiently modulate cardiac excitability. The purpose of the project is to characterize the properties of the sodium permeability in these neural cells and to elucidate how their mutations may contribute to ICN electrophysiological perturbations and potentially to cardiac channelopathies. To reach this goal, we will use several approaches consisting in cellular electrophysiology, molecular biology and biochemistry on mouse models.  This will allow us to target specifically i) the characterization of expression and biophysical properties of VGSC expressed in ICN , ii) the characterization of the molecular and functional impact of VGSC modulations on ICN electrophysiological properties and iii) the assessment of structural remodeling of the intracardiac nervous system in the context of channelopathies such as BS. The global and quite innovative objective of this project is to decipher how the ICN may participate to, modulate or control cardiac arrhythmias in sodium channelopathies.

Requested knowledge and skills:
The recruited person must have knowledge of electrophysiology and cardiovascular and neuronal physiology. A previous internship experience in one of these areas would be appreciated.
The recruited person must also have good theoretical and if possible practical knowledge in the patch clamp technique, in molecular biology and in biochemistry.
The successful applicant must also have the willingness and enthusiasm to work independently while being able to communicate with the various scientists involved in
this project. The ideal candidate should be curious, and should enjoy solving problems and developing new
technologies with personal creativity and innovation.

Requirements

  • Research Field: Biological sciences » Biology

  • Education Level: Master Degree or equivalent

  • Research Field: Neurosciences » Neurophysiology

  • Education Level: Master Degree or equivalent

  • Research Field: Medical sciences » Health sciences

  • Education Level: Master Degree or equivalent

Skills/Qualifications

The recruited person must have knowledge of electrophysiology and cardiovascular and neuronal physiology. A previous internship experience in one of these areas would be appreciated.
The recruited person must also have good theoretical and if possible practical knowledge in the patch clamp technique, in molecular biology and in biochemistry.
The successful applicant must also have the willingness and enthusiasm to work independently while being able to communicate with the various scientists involved in this project. The ideal candidate should be curious, and should enjoy solving problems and developing new technologies with personal creativity and innovation.

Additional Information :

Work Location(s)

Number of offers available: 1

Company/Institute: University of Poitiers, PRéTI Laboratory

Country: France

Where to apply

E-mail: aurelien.chatelier@univ-poitiers.fr

Contact

City: Poitiers

Website: https://preti.labo.univ-poitiers.fr/

Street: 1 rue Georges Bonnet - Postal Code: 86073

Contact