Date d'arrivée à l'ITMO : Vendredi 27 Janvier 2023
ERC-funded project: regeneration of spinal locomotor circuits in salamanders
Salamanders, regeneration, neuroscience
DETAILS OF THE OFFER
Salamanders can swim underwater and walk on ground. Their spinal cord regenerates after a full transection and the animal recovers voluntary locomotion after a few weeks. How this occurs is largely unknown. Genetic dissection of salamander neural circuits is now feasible with methods for manipulation, elimination, and visualization of genetically-defined cells. Such approaches can be combined with patch-clamp electrophysiology, calcium imaging, optogenetics, tracing and movement analysis (Ryczko et al. 2020 Trends in Neurosciences). The candidate will use genetic tools, calcium imaging, electrophysiology and movement analysis based on deep learning and neuroanatomy to study salamander locomotor circuits. The work will be carried out in collaboration with a team of modelers and roboticists (Pr. Ijspeert, EPFL, Switzerland) and experts in genomics (Pr. Simon, Karolinska Institute, Sweden).