Ville | Marseille |
Pays | France |
Texte de l'offre | From birth, mammals have to find food to ensure growth and survival. Suckling must be initiated quickly after birth and then maintained and controlled. It is a complex process involving interactions between sensory and motor neuronal pathways. The development of these circuits is disturbed in a variety of developmental disorders leading to long-term metabolic, behavioural and cognitive dysfunctions. Interestingly, we showed in a genetic mouse model of a neurodevelopmental disorder, involving the MAGEL2 gene, that oxytocin is required to trigger the suckling activity. We will perform an integrative study and use behavioral, electrophysiological, cellular and functional neuroanatomical analyses to trace the neuronal circuit of suckling involving the oxytocin neurons, to decipher the action of oxytocin on motor pathways and to assess the therapeutic action of an early oxytocin treatment. We will conduct this project thanks to a panel of genetic and pharmacogenetic tools. |
| Type d'emploi | Thèse - PhD |
Type de contrat | CDD 3 years |
Date limite de candidature | 30/08/2022 |
Date début de fonction | October 2022 |
| Plus d'informations | Annonce de recrutement |
Information contact |