The main aim of the project is to understand the molecular and cellular bases of focal cortical dysplasia and epileptogenesis. To achieve this, FCD somatic mutations will be introduced in the developing mouse brain to reproduce the disease phenotype, and study the underlying cellular and molecular mechanisms. The successful candidate should be able to use multiple techniques such as genetic engineering and Crispr-editing, in utero electroporation, high-throughput in vivo screening, imaging and single-cell omics.
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