itneuro
itneuro





Post-doctoral in synchrotron & super resolution imaging applied to Neurosciences


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  • Type d'offre : CDD (2 ans)
  • Ville : Bordeaux (France)
  • Statut : Recrutement en cours
Date d'arrivée à l'ITMO : Jeudi 02 Décembre 2021

Post-doctoral position (2 years) in synchrotron and super resolution imaging applied to Neurosciences

Imprimer l'offre

Ville

Bordeaux

Pays

France

Texte de l'offre

Missions
Investigate the molecular mechanisms of metal-induced synaptic toxicity in Alzheimer's disease using synchrotron X-ray fluorescence and super resolution STED imaging.

Scientific project
Alzheimer's disease can be triggered and/or accelerated by environmental exposure to metal contaminants. A novel mechanism of metal-induced neurotoxicity will be evaluated based on the direct interaction of metals with the synaptic cytoskeleton architecture. Interactions of environmental neurotoxic metals with synaptic cytoskeleton proteins will be characterized at the cellular and molecular levels, and prevention strategies involving essential metals will be evaluated. The presence of environmental toxic metals in synapses, and the consequent alteration of synaptic structures, will be characterized using state-of-the-art synchrotron X-ray fluorescence nano-imaging of metals correlated with super-resolution STED microscopy of proteins (Domart et al., eLife, 2020).

Activities
 Sample preparation and performance of STED and immunofluorescence microscopy of cytoskeleton proteins on cultured primary neurons.
 Sample preparation and participation to synchrotron X-ray fluorescence experiments on large scale physics facilities in France and Europe.
 Data analysis for quantitative and correlative imaging.
 Interpretation of data in the context of molecular mechanisms of synaptic toxicity and environmental exposures.


Skills
PhD in Biology, Chemistry, or Physics.
Experience in cell biology, synchrotron and/or super resolution imaging is desirable
 Ability to work meticulously
 Interest in innovative imaging techniques and data analysis
 Interest in the field of health/environmental research
 Ability to communicate and write in English


Work Context
We offer an attractive work environment within the University of Bordeaux including cooperation with the Interdisciplinary Institute of Neurosciences (IINS, team D. Choquet) and with the Laboratory of Interactions Metal Proteins at the University of Aix-Marseille (BIAM, team C. Berthomieu and V. Malard).

Date de fin de publication :

01/12/2021

Type d'emploi

Post-Doctorat - Post-Doctoral position

Type de contrat

CDD 2 years

Date limite de candidature

January 15, 2022

Information contact

Requests for information as well as applications accompanied by a complete CV, a letter of motivation and the contact information of 3 references should be sent to Richard Ortega (ortega@cenbg.in2p3.fr).

Votre courriel

ortega@cenbg.in2p3.fr

 

Contact


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