We are looking for a highly-motivated Post-doctoral researcher to join a project studying mitochondria during neural development.
The hippocampus is an important brain structure for learning and memory. Hippocampal development relies on well-orchestrated neuronal migration that occurs during embryonic development. We previously demonstrated that doublecortin, a microtubule associated protein, when mutated in mice generates neuronal layering defects in the CA3 region of the hippocampus. Organelle defects are observed in mutant cells. It is known that cytoskeleton remodeling is crucial for correct neuronal migration, but how mitochondrial function regulates migratory dynamics is poorly understood. To elucidate this, the Post-doctoral researcher will work at the interface of cell biology and biophysics, in collaboration also with Stéphanie Bonneau at Laboratoire Jean Perrin (Sorbonne University), using state-of-the-art microscopy approaches such as SIM, spinning-disk and confocal microscopy.
The candidate should have a PhD in Life Sciences and a strong interest in neural development together with a solid expertise in microscopy and quantitative imaging. A background in metabolism would also be useful. The candidate will take part in experimental design, will conduct experiments, perform analyses and contribute actively in research communication. He/she should be able to work as part of a group, have excellent organizational skills and a good level of spoken and written English.