One-year post-doctoral position in an electrophysiology lab.
We are seeking highly motivated candidates to join us on a running project (2019-2023) on the molecular mechanisms of sensory neurogenesis. We study in particular the nociceptors, the specialized peripheral neurons that detect painful stimuli.
Starting date is flexible / possibility to start in May 2021
We aim to understand the role and mechanism of action of the Prdm12 gene. Prdm12 encodes an evolutionarily conserved epigenetic regulator of gene expression that has been found mutated in patients that suffer from Congenital Insensitivity to Pain. We expect that the results of our work will help in the development of new strategies for treating pain.
The positions are funded by the Walloon government within the frame of the "Win2wal" program. The research will be performed in the laboratory of Neuroscience (Dr. Laurence Ris) at the University of Mons.
The research group Neuroscience is embedded within the Health Research Institute at UMONS. Our approach consists of a combination of electrophysiological, molecular and cellular approaches. We develop and apply state-of-the-art electrophysiogical techniques in vivo, ex-vivo in acute slices and in vitro in primary and organotypic cultures. www.umons.ac.be/neuro
The experiment performed will be whole cell patch-clamp on DRG neurons prepared from WT and conditional KO mice (Prdm12) or overexpression mice. Basal electrophysiological properties, excitability and ionic currents (Na VDCC, Ca TRPV).
Interested candidates should send a letter of motivation describing past research experiences and full CV to:
Laurence Ris (Laurence.RIS@umons.ac.be) together with the name and e-mail address of 2 references.
Selected related publication:
Nagy et al., (2015). The evolutionarily conserved transcription factor PRDM12 controls sensory neuron development and pain perception. Cell Cycle, 14(12), 1799-1808.