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Research-engineer (stem cells-derived neural organoids)


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  • Type d'offre : CDD 36 mois
  • Ville : Paris
  • Statut : Recrutement en cours
Date d'arrivée à l'ITMO : Jeudi 24 Septembre 2020

Research engineer position to develop a human stem cells-derived neural organoids facility

Imprimer

A three-year research-engineer position has been funded by the Labex "Who Am I" at Université de Paris to develop a facility for the phenotyping of human iPSC-derived 3D neuronal organoids.
The Labex "Who Am I" supports the "Human Neural Organoids" research project, which aims to characterize the molecular and cellular mechanisms regulating the normal or pathological development of the human central nervous system. This collaborative project, coordinated by Valérie Mezger (Unité Epigénétique et Destin Cellulaire, EDC research unit), currently involves seven research teams within the Epigenetic and Cell Fate Unit (EDC; S. Ait-Si-Ali, C. Francastel, V.Mezger), Institut Jacques Monod (IJM: N. Borghi, V.Doye, V. Ribes), and Institut Cochin (D. Passaro).


With the help of a technician, the engineer will establish and run the enSCORE (engineered Spinal and Cortical Organoid coRE) facility located within the Institut Jacques Monod for the phenotyping of iPSC-derived 3D neural organoids. He/she will select and establish standardized protocols to generate brain cortical and spinal organoids from control, patient-derived, or genetically engineered human iPSCs and to facilitate their characterization and quality control. He/she will be responsible for training the members of the EDC, IJM and Institut Cochin teams contributing to the "Human Neural Organoids" collaborative project to produce organoids and will accompany them in the adaptation and development of innovative protocols.


He/she will also benefit from fruitful interactions with the genome and epigenome editing facility (GENIE, Genome ENgineering In Epigenetics), and the L3 Vectorology laboratory (located within the EDC research unit), and with the imaging facilities (ImagoSeine at IJM and IMAG'IC at Institut Cochin).


We are looking for motivated candidates with a strong background in stem cell culture and differentiation and interest in technological developments, willing to join an interdisciplinary environment, involving interactions between biologists and physicists.


The earliest starting date is November 1, 2020. Candidates should send their application to the selection committee at enscore@services.cnrs.fr. Please include "IR/IPS neural organoids" in the email header.

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